L-Proline
L-Proline is an amino acid and precursor (with vitamin C) for collagen, the building block of the structure of tendons, ligaments, arteries, veins and muscles (the heart muscle). It is important in wound healing.
Published Clinical Studiesclin
L-Proline
1
Co-administration of proline and inorganic iron enhance the improvement of behavioral and hematological function of iron-deficient anemic rats.
Kitajima H, Shiomoto H, Osada K, Yokogoshi H.
Laboratory of Nutritional Biochemistry, School of Food and Nutritional Sciences, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan. h.kitajima@po.rd.taisho.co.jp
We investigated the interrelationships between behavior and serum amino acid concentrations in iron-deficient anemic rats. Concentrations of proline, alanine, glycine, and phenylalanine in serum samples were significantly higher than those in rats fed a normal diet, while serum threonine, glutamic acid, and valine levels were significantly lower. Activities of locomotion, rearing, hole-poking, and grooming, determined by using a hole board apparatus, were significantly reduced in anemic rats. The supplementation of inorganic iron and amino acids proline, arginine, or glutamic acid to the normal diet lead to the recovery of normal behavior. Proline enhanced a significant increase in the number of red blood cells and hemoglobin by the supplementation of iron alone. We propose that the combination of amino acid (especially proline) and inorganic iron might lead to an improvement in behavioral disorders caused by iron-deficient anemia.
PMID: 12882390 [PubMed - indexed for MEDLINE]
Plasma proline and leucine kinetics: response to 4 wk with proline-free diets in young adults.2
Hiramatsu T, Cortiella J, Marchini JS, Chapman TE, Young VR.
Am J Clin Nutr. 1994 Aug;60(2):207-15.
School of Science, Massachusetts Institute of Technology, Cambridge 02142-1308.
The effects of removing proline from the diet on plasma leucine and proline kinetics were investigated. After a 1-wk control period, during which young adult men received a diet containing a complete L-amino acid mixture, seven subjects were given for 4 wk a diet devoid of proline (group 1); six received a diet devoid of proline, arginine, aspartate, glutamate, and serine (group 2); and seven continued with the complete diet (group 3). At the end of the control and 4-wk periods subjects were given a continuous, (3-h fast, 5-h fed) intravenous infusion of L-[1-13C]leucine and L-[5,5-2H]proline. Plasma proline was reduced significantly, especially during the fed state, in groups 1 and 2 after the 4-wk diet periods. Small but statistically significant (P < 0.05) reductions occurred in nonoxidative leucine disappearance and leucine appearance during the fasted state in group 2. Proline fluxes decreased by approximately 50% in fasted and fed states in groups 1 and 2. Mean de novo proline synthesis during the fasted state declined markedly (P < 0.05) after 4 wk in groups 1 and 2.
Publication Types:
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Clinical Trial
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Randomized Controlled Trial
PMID: 8030598 [PubMed - indexed for MEDLINE]
3
Clinical trials of vitamin B6 and proline supplementation for gyrate atrophy of the choroid and retina.
Hayasaka S, Saito T, Nakajima H, Takahashi O, Mizuno K, Tada K.
Br J Ophthalmol. 1985 Apr;69(4):283-90.
Five patients with gyrate atrophy of the choroid and retina were examined ophthalmologically, especially ophthalmoscopically, to evaluate trials of vitamin B6 (pyridoxine) or supplementary proline. The oral administration of vitamin B6 was tried in two patients. The vitamin did not alter the serum ornithine level and the progression of chorioretinal atrophy in one patient (case 2). Despite a reduced serum ornithine level following vitamin B6 administration, chorioretinal atrophy progressed gradually in another patient (case 3). Supplementary proline was tried in four patients. Despite the supplementation the serum proline level did not increase, and the chorioretinal atrophy progressed in one patient (case 2) who received both vitamin B6 and proline. Supplementary proline minimised the progression of gyrate atrophy in the youngest patient (case 1) and halted the progression in two others (cases 4 and 5). Supplementary proline may possibly lessen the progression of chorioretinal lesions in gyrate atrophy.
Publication Types:
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Case Reports
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Clinical Trial
PMID: 3922397 [PubMed - indexed for MEDLINE]
Referencesref
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Patient report: hypertension and osteoarthritis.(Letters to the Editor) Townsend Letter for Doctors and Patients, August-Sept, 2003, by Dale Humpherys.
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Joint health and texture. (R&D Applications). Prepared Foods, Feb, 2003, by Fran LaBell.
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Hypochlorhydria: A Review.(part 2) Townsend Letter for Doctors and Patients, Nov, 2001, by Judy Kitche.
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Colostrinin, proline-rich polypeptide complex from ovine colostrum – a long-term study of its efficacy in Alzheimer’s disease. Med Sci Monit 2002; 8 (10): PI93-96; Leslek, J., Inglot, A.D., Janusz, M., Byckiewicz, F., Kiejna, A., Georgiades, J., Lisowsi, J.