Serrapeptase

Clinical Studies
References

Serrapeptase lysozyme (or Serratia peptidase) is an enzyme that specifically attacks the cell wall of gram-positive bacteria (which are able to cause a number of infections). Lysozyme is also a key component in strengthening the natural defences of the body against infections. It induces fibrinolytic, anti-inflammatory and anti-edemic activity in a number of tissues. It helps to reduce pain due to its ability to block the release of pain-inducing amines from inflamed tissues.

This proteolytic enzyme is isolated from the non-pathogenic enterobacteria Serratia E15. When consumed in normal tablets or capsules the enzyme is destroyed by acid in the stomach. However, enteric coated tablets enable the enzyme to pass through the stomach unharmed and be absorbed in the intestine. Serrapeptase is found in negligible amounts in the urine, suggesting that it is transported directly from the intestine into the bloodstream.

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Clinical Studiesclin

Reduction of postoperative swelling. Objective measurement of swelling of the upper ankle joint in treatment with serrapeptase-- a prospective study

[original article in German]

Esch PM, Gerngross H, Fabian A.

Using a quantitative standardized procedure, the swelling of the ankle produced by supination trauma was measured. In the 66 patients with fresh rupture of the lateral ligament treated surgically at our Department between December 1986 and April 1987, a prospective study of the effect of serrapeptase (Aniflazym) on post-operative swelling and pain was carried out in 3 randomized groups of patients. In the group receiving the test substance, the swelling had decreased by 50% on the third post-operative day, while in the other two control groups (elevation of the leg, bed rest, with and without the application of ice) no reduction in swelling had occurred at that time. The difference is statistically significant (p = 0.013). Decreasing pain correlated for the most part with the reduction in swelling. Thus, the patients receiving the test substance more rapidly became pain-free than did the control groups. On the basis of these results, serrapeptase would appear to be an effective preparation for the post-operative reduction of swelling, in comparison with the classical conservative measures, for example, the application of ice.

Publication Types:

  • Clinical Trial
  • Randomized Controlled Trial

PMID: 2647603 [PubMed - indexed for MEDLINE]

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Referencesre

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